The weekend show will focus on food and travel, departing in both content and procedure for the news network. CNN usually does its programming in-house, but in this case an outside production company tied to Bourdain will make the series.
The show will air Sunday nights in prime time and will be repeated on Saturday nights. The show will feature cultures around the world, highlighting dining traditions.
Bourdain has done programs on both the Travel Channel and Food Network, and also appeared in the Bravo competition Top Chef.
The Associated Press contributed to this report.