The film took in $7.5 million on its first night of midnight screenings. As if that wasn't enough, the film made $35 million in the United States on its first day. That's a record for a film opening on a Tuesday.
The new launch for the Marvel Comics superhero outdid the previous best Tuesday debut of $27.9 million for "Transformers," which also opened the day before the Fourth of July in 2007.
"The Amazing Spider-Man" is expected to do big business through the weekend as well. Some box-office trackers expect it to bring in $120 million in its first six days.
The high numbers show the resilience of the Spider-Man brand, which set box-office records from 2002 to 2007 with the three films directed by Sam Raimi and starring Tobey Maguire as the web-slinging superhero.
There was a falling out with Raimi and distributor Sony on the fourth film. So, the franchise started over, with Marc Webb as the director and Andrew Garfield donning Spider-Man's red and blue suit.
"The Amazing Spider-Man" retells the story of how a bite from a radioactive spider endows gangly teen Peter Parker with super strength, agility and senses. The film co-stars Emma Stone, Rhys Ifans, Martin Sheen and Sally Field.
The Associated Press contributed to this report.