Authorities say the couple entered the nail salon around 4:30 p.m. Thursday.
The man indicated he had a gun tucked in his waistband, while the woman took the purses of the customers and one employee. The suspects fled in a light blue compact car.
A few months ago, the same salon was robbed by a couple and police believe this could be the same pair.
Investigators say the suspects could also be responsible for robbing two nail salons in Burbank in the past two weeks.