The incident happened on the 700 block of East Providencia Avenue. Officers found the victim just before 11 p.m. Thursday after responding to calls of shots fired.
The man was rushed to Los Angeles County-USC Medical Center, where he was pronounced dead early Friday morning.
No arrests have been made and there was no word yet on the victim's identity or what may have led up to the shooting.
Anyone with information is urged to call the Burbank Police Department at (818) 238-3246.