The 26-year-old actress was being charged with third-degree assault after she allegedly struck a woman in the face with her hands. The fight happened around 4 a.m. ET at Club Avenue in Manhattan.
The "Mean Girls" star is a regular at the club and was banned there earlier this year following an incident in which she tweeted about Justin Timberlake.
The fight wasn't the only drama brewing for Lohan on Thursday. Over on the West Coast, the Santa Monica City Attorney's Office filed three charges against the actress in relation to a car wreck in June. Lohan and her assistant went to the hospital following that crash, but no one was seriously injured. She has been charged with willfully resisting or obstructing a peace officer in the course of their duties, giving false information to a peace officer and reckless driving - all misdemeanors.
This is just the latest in a string of troubles Lohan has encountered this year.
In October, police were called to her childhood home on Long Island after a report of a fight between Lohan and her mother. But police found "no criminality" in that incident.
Lohan was previously arrested in September outside another New York nightclub at the Dream Hotel. A pedestrian claimed Lohan struck him with her car and did not stop. Lohan was arrested for leaving the scene of an accident. Police said no alcohol was involved. The Manhattan District Attorney's Office decided not to prosecute the case.
About a week after that incident, Lohan told authorities a man grabbed her in a New York hotel room in an argument over cellphone photos. The man was initially arrested, but the arrest was voided hours later when the charge could not be substantiated, law enforcement officials said.
In May, she was cleared of allegations that she hit a Hollywood nightclub manager with her car.
Lohan remains on informal probation for taking a necklace from a Venice jewelry store without permission last year. The actress' unsupervised probation is scheduled to end in May 2014.
The Los Angeles City Attorney's office is now considering revoking that probation. Lohan's attorney nor her publicist are commenting on the star's latest troubles.
As far as the assault charges go, Lohan's New York attorney Mark Heller says his client is the victim of someone trying to capture 15 minutes of fame. He expects the charge to be dismissed and Lohan totally exonerated.