The one-vehicle crash occurred around 7:15 a.m. Sunday just south of the city of Warren, about 60 miles east of Cleveland near the Pennsylvania state line.
Eight people were onboard the Honda Passport which veered off the left side of a road, hit a guardrail, and overturned. According to the Ohio State Highway Patrol, the SUV landed in a pond.
Two of the six teenagers killed in the crash died at St. Joseph Health Center where they were receiving treatment for "hypothermic drowning trauma". Julie Gill, St. Joseph Health Center nursing supervisor, said the two teens, both 15, were brought to the hospital in "full cardiac arrest" after having been submerged in cold water.
The two victims who survived the fatal crash were treated for bruising and other injuries and released.
The victims killed were between 14 and 19 years old. Their identity has been withheld pending notification of kin.
The crash remains under investigation. The teenage victims' intended destination remains unclear.