According to longtime publicist Sanford Brokaw, Brothers died Monday in New York City after a long-term illness.
She became famous after entering a television quiz show called "The $64,000 Question." She became the only woman to ever win the show's top prize.
She became co-host of "Sports Showcast" in 1955, and two years later, NBC offered her a trial on an afternoon television program in which she advised on love, marriage, sex and child-rearing. Its success led to a nationally telecast program that addressed taboo subjects as menopause, frigidity, impotence and sexual enjoyment.
Her syndicated television and radio shows lasted four decades.
Brothers also offered advice in newspaper and magazine columns, published 15 books and made cameo appearances on popular shows like "Happy Days" and "The Simpsons."
The Associated Press contributed to this report.