The shooting occurred near the 500 block of 95th Street near Figueroa Avenue around 11:30 p.m.
Investigators say the woman was walking with her boyfriend when a car drove by and opened fire.
One of the rounds struck the unidentified woman in the head. The man was not hit.
Police say the fatal shot was fired from a white sedan with four males inside.
The investigation is ongoing. Police are investigating whether the shooting was gang-related.