The closures will involve both eastbound and westbound lanes of west Olympic Boulevard, between south Beloit Avenue and Cotner Avenue.
The lane closures will happen between 9 a.m. and 3 p.m., and then again from 9 p.m. to 5 a.m. every day except the weekend.
During the closure, crews will be demolishing and replacing a curb and a sidewalk in the area.
The work will continue through Oct. 18.