The announcement on Wednesday rounds out the lineup of performances previously announced, including Luke Bryan, Miley Cyrus, Florida Georgia Line and Lady Gaga. Other musical guests include Ke$ha, Imagine Dragons, Kendrick Lamar, Macklemore, One Direction, Justin Timberlake and Pitbull.
In addition to gracing the stage, Pitbull will also be this year's host. This marks the first time the award ceremony has a host since 2008.
Jennifer Lopez will perform a tribute to music legend Celia Cruz.
Katy Perry is slated to open this year's show with her new single "Unconditionally." The 29-year-old pop star said she plans to step it up in what she believes is her first chance to open an awards show.
"You take that into consideration, that you are kind of like setting the tone for everyone in the evening, so you always bring out the big guns in the beginning," Perry said, later adding: "I always seem to be flying in on something or coming out of something. I like to entertain the kids, I really do."
TLC is scheduled to perform with a special unannounced guest.
Winners will be determined by fans voting online at AMAvote.com. Fans can also vote on Twitter.
The show will be broadcast from the Nokia Theatre at L.A. Live in downtown Los Angeles on Sunday, Nov. 24 at 8 p.m. PT on ABC.
ABC will air a pre-show "On The Red Carpet at The American Music Awards" at 7 p.m. PT.
The Associated Press contributed to this report.