The actor crashed his 2011 Mercedes Benz into a Department of Transportation truck on the westbound 101 Freeway at Balboa Boulevard shortly before 2 a.m.
CHP officials said a witness called 911 to report an impaired driver prior to the crash. The caller said Kattan was weaving in and out of lanes at slow speeds.
Crews were conducting maintenance on a guardrail on the right shoulder of the freeway. Orange cones, sign boards, and flashing arrows were placed to alert drivers of the lane closure, but Kattan ran over the cones and slammed into the back of the truck.
Kattan's Mercedes sustained major front end damage in the crash. The back of the DOT vehicle was also damaged.
The 43-year-old was not injured and exited the vehicle on his own recognizance. No Caltrans workers were hurt. Kattan suffered a bloody nose caused by the airbag in his car.
"The officer did do a field sobriety test on him, which he was unsuccessful at," said Officer Leland Tang with the CHP.
Responding officers arrested Kattan on suspicion of driving under the influence of drugs. He was booked at the Van Nuys jail and released after posting $15,000 bail.
Tang says the comedian told officers he was taking prescription drugs. Toxicology test results to verify what was in his system are expected in three to four weeks.
On Monday afternoon, Kattan tweeted the following message regarding his DUI arrest: "Those concerned or just adding gossip: I'm fine, passed all tests, released without bail, have drivers license, cop offered to drive me home."
"If you dont have something nice to say, don't say it at all," he added.
The "SNL" alum said he was tired following a 15-hour flight.
"I just got back from a 15hr flight after touring out of the country. I was exhausted. The Police were so kind. I'm lucky nobody was hurt," he tweeted.
Kattan faces a misdemeanor DUI charge and is due in court on March 3.
Kattan, who was on "SNL" from 1996 to 2003, was best known for the character Mango. He also starred alongside Will Ferrell in the 1998 film "A Night at the Roxbury."
The Associated Press contributed to this report.