The crash involved multiple vehicles on the freeway north of Jamboree Road around 10:38 p.m. All northbound lanes of the 5 were closed and traffic was being diverted off the freeway at Jamboree.
One person died in the fiery crash, officials said. Another man suffered burns and a woman suffered minor injuries, authorities said.
The Jamboree on-ramp to the freeway was also closed, but both the on-ramp and freeway were reopened early Tuesday morning.
The cause of the crash is under investigation.