The crash, involving a 2002 Honda Accord, was reported just after 6 p.m. near the Sherman Way exit of the 405.
One victim was pronounced dead at the scene after suffering massive crush injuries, according to the Los Angeles Fire Department.
Three patients were transported to a hospital -- two in serious-to-critical condition. The other person was in fair condition, with injuries that were described as non-life threatening.
Haskell Avenue was closed near the crash site as an investigation got underway.