The collision occurred about 3 a.m. at the intersection of Washington Boulevard and La Brea Avenue, according to the Los Angeles Police Department. News video showed a black Kia Soul with severe front-end damage scene.
A verbal altercation followed, involving a possible witness to the crash and a male driver, the LAPD said. The suspect stabbed the victim, who was transported to a hospital and later died.
The assailant fled on foot and remained at large. A detailed description was not available.
The deceased victim was not immediately identified.