Security was tight at the 21,000-capacity arena in downtown, where the celebration of life event began shortly after 11 a.m.
The beloved hip-hop artist's untimely death generated countless tributes from musicians, elected officials and professional athletes. Thursday's service began with a montage of photos showing Hussle at various stages of his life, alongside family members and fellow rappers.
The private funeral service for Hussle will be held Friday afternoon at Forest Lawn Hollywood Hills.
Minister Louis Farrakhan of the Nation of Islam delivered remarks that hailed Hussle's ability to bring different factions together. Karen Civil, a blogger and media figure, read aloud a letter of condolence from former President Barack Obama.
MORE: Obama remembers Nipsey Hussle in letter read at memorial service
"I've never meet Nipsey, but I've heard his music through my daughters, and after his passing I had the chance to learn more about his transformation and his community work. While most folks look at the Crenshaw neighborhood where he grew up and only see gangs, bullets and despair, Nipsey saw potential. He saw hope. He saw a community that even through its flaws taught him to always keep going. He choice to invest in that community rather than to ignore it," the Obama letter read. "He set an example for young people to follow and is a legacy worth of celebration. I hope his memory inspires more good work in Crenshaw and communities like it. Michelle and I send our sympathies to Lauren, Emani, Kross and his while family and to all those who love Nipsey."
Among those who also spoke at Thursday's service were rapper Snoop Dogg and radio DJ Big Boy. Stevie Wonder performed his song "Rocket Love."
Snoop Dogg on friend Nipsey Hussle: 'He was a fighter'
Hussle's mother, Angelique Smith, spoke of finding peace through her pain, referring to her son by his given name.
"My son, Ermias Joseph Ashgedom, was a great man," she said.
The slain rapper's girlfriend, Lauren London, spoke about Hussle as a one-of-a-kind man.
"Ermias used to say that you can't possess people, you experience them, and I am so honored and blessed that I got to experience such a man," she said.
A hearse carrying Hussle's coffin traveled from an intersection near USC and made its way into the neighborhood where Hussle's The Marathon clothing store is located in a strip mall. The procession, under the watchful eye of Los Angeles Police Department officers, traveled to its destination at a funeral home in the Crenshaw District.
The procession was lined by thousands of mourners and fans throughout the route. Although there were huge crowds expressing their emotions, the day remained peaceful aside from a few minor incidents.
At a few points, people in the crowd panicked, causing brief moments of chaos and at least one stampede. No serious injuries were reported during the event.
The 33-year-old Hussle was fatally shot March 31 while standing in front of his South L.A. store near the intersection of Slauson Avenue and Crenshaw Boulevard.
Police later arrested Eric R. Holder Jr. as the suspect in Hussle's killing. Holder, who has pleaded not guilty in the case, allegedly had a personal dispute with Hussle that culminated in the deadly shooting.
A mural on a Los Angeles basketball court depicts slain rapper and community leader Nipsey Hussle. Thousands are set to honor Hussle at a memorial service at Staples Center. https://t.co/KnxNtNmeMV pic.twitter.com/tktGx2Hzm6— ABC7 Eyewitness News (@ABC7) April 11, 2019
Hussle, an Eritrean-American whose real name was Ermias Asghedom, was a father of two who was engaged to actress Lauren London. He had recently purchased the strip mall where The Marathon is located and planned to redevelop it into a mixed-use commercial and residential complex.