Authorities said the fire started after the bus blew a tire just west of Fruit Street around 11:30 p.m. Sunday.
Nearly 40 people were inside the bus at the time. Fortunately, they were all able to get out and wait for another bus. No one was injured.
Crews were cleaning up a fuel leak caused by the wreck.
California Highway Patrol began reopening lanes around 5 a.m. but one lane and the Fruit Street on-ramp were expected to be closed until late morning.
SIGALERT UPDATE IN LA VERNE: SB I-210 WEST OF FRUIT ST #3 LN REMAINS CLOSED UNTIL APPROX 9:00 AM DUE TO A VEHICLE FIRE CLEAN UP— CHP Southern Div. (@CHPsouthern) October 12, 2015