"Rene Angelil, 73, passed away this morning as his home in Las Vegas after a long and courageous battle against cancer," a rep for the couple told People magazine. "The family requests that their privacy be respected at the moment; more details will be provided at a later time."
Angelil, who married the famed singer in 1994, had been Dion's manager for more than 30 years. He stepped down from his role in 2014 after his throat cancer returned. He first battled cancer in the late 1990s.
Also in 2014, Dion, 47, took some time off from her regular residency in Las Vegas to be with her husband. Dion and Angelil have three sons together.
Angelil is survived by his wife and their sons -- Rene-Charles, 14, and twins Nelson and Eddy, 5.
PHOTOS: Celebrities and notable figures who have recently passed away
ABC News Press contributed to this report.