"ESPN and everyone in the sports world have lost a true friend and a uniquely inspirational figure in Stuart Scott," said ESPN president John Skipper. "His energetic and unwavering devotion to his family and to his work while fighting the battle of his life left us in awe, and he leaves a void that can never be replaced."
After joining the network in 1993 for the launch of ESPN2, Scott became a leading voice on ESPN's SportsCenter.
PHOTOS: ESPN Sports anchor Stuart Scott
Scott was one of ESPN's most recognizable and quotable personalities with famous catchphrases such as "Boo-ya" and "As cool as the other side of the pillow."
Scott received the Jimmy V Perseverance Award at the 2014 ESPYs. During his acceptance speech, he shared his approach to fighting cancer.
"When you die, that does not mean that you lose to cancer. You beat cancer by how you live, why you live, and the manner in which you live. So live. Live. Fight like hell," Scott said.
Scott is survived by his two daughters, 19-year-old Taelor and 15-year-old Sydni, his parents, and his three siblings.
ESPN says Scott's girlfriend, Kristin Spodobalski, was with him and cared for him every step of the way as he went through several surgeries, chemotherapy, radiation and clinical trials.