The truck went off the side of the freeway, plowed through some bushes and crashed into the side of a building off Nogales Street shortly before 5:30 a.m.
The crash ignited a fire, which was quickly knocked down by firefighters.
The driver of that big rig was airlifted to Usc Medical Center in unknown condition.
Emergency crews shut down two lanes of the westbound 60 Freeway, but all lanes have since reopened.
The cause of the crash is under investigation.