The collision, which left the semitrailer fully engulfed in flames, was reported shortly before 4 a.m. at Dale Evans Parkway, according to the California Highway Patrol.
No one was injured in the crash, and alcohol and drugs were not considered to be a factor in the collision, CHP officials said.
The agency issued a SigAlert at 4:52 a.m. on the 15 Freeway, a major artery between the Southland and Las Vegas.
The closure was initially expected to last until at least 8:30 a.m., Caltrans said. Northbound traffic was temporarily diverted at Highway 395 and back to the 15 Freeway via Highway 58.
Shortly before 10 a.m., Caltrans announced on Twitter that all lanes were open in the 15 in both directions.
The cause of the incident was under investigation.
Working a TC with multiple vehs of fire NB 15 North of N Stoddard. Fwy closed. https://t.co/7pYh7LHjtq— Apple Valley FPD (@AVFPD) March 30, 2017