The chain-reaction crash was reported about 2:40 a.m. on Cahuenga Boulevard, near the 101 Freeway, according to the Los Angeles Police Department. No injuries were reported.
The man behind the wheel of a white Range Rover grabbed his belongings and ran away, witnesses said. A description of the suspect was not available.
Erin Vega, whose car was totaled in the pileup, said such crashes are not uncommon at the location.
"This is our sixth car totaled and our seventh car hit," she said, "and it makes me worried because I wonder if there will be a time when we're taking out the trash or someone is walking their dog or crossing the street and instead of being property it's going to be a life."
Residents said they are fed up with the frequent crashes and many believe it's time for the city to start taking measures to prevent them.
"The solution would be to put a traffic light, speed bump, crosswalk, something," said resident Rich Kane. "I've been trying to fight the city to get them to do it for years now."