Officers with the San Gabriel Police Department and California Highway Patrol were in pursuit of the suspect, who was fleeing in a white Nissan Rouge with Colorado license plates.
Police later identified the suspect as a Colorado resident, 21-year-old Christian Castrellon.
CHP said the suspect was involved in a road rage incident with San Gabriel police at about 11:25 a.m.
San Gabriel police said the chase started on the westbound 10 Freeway at Rosemead Boulevard.
The suspect, who hit speeds up to 110 mph, led authorities through downtown Los Angeles, South Los Angeles, Carson, Wilmington, Bellflower and Cerritos.
Police chased the suspect down the 110 Freeway until he exited near West Anaheim Street. The suspect hit speeds hit up to 80 mph on surface streets and was seen hitting several cars and driving on the wrong side of the road.
The suspect got back on the 110 Freeway northbound and headed toward downtown Los Angeles again.
After taking the 91 Freeway heading eastbound in Carson, the suspect was seen intentionally striking a patrol cruiser.
While attempting to make a dangerous maneuver, the suspect's SUV spun out of control and crashed down an embankment in Cerritos.
The suspect, who was acting erratically, attempted to flee on foot but was taken into custody shortly after.
Authorities said the suspect was a man in his 20s from Montrose, Colorado, and was under the influence of a very potent form of marijuana commonly known as marijuana wax or honey oil.
The suspect was booked on multiple charges of assault with a deadly weapon and felony evading, according to officials.