"I am honored to serve in the role of First Lady, and look forward to working on behalf of the American people over the coming years," she said in a statement accompanying the photo's release.
The photo was taken in the first lady's "new residence at the White House," according to the release.
Mrs. Trump, who turns 47 on April 26, has yet to move to Washington full-time. She currently spends most of her time at Trump Tower in New York City but has plans to move to the White House with son Barron once he finishes the school year in New York.
ABC News and KGO-TV contributed to this report.