James, 35, is coming off a season-high 40 points in a win over the New Orleans Pelicanson Tuesday.
In December 2018, he suffered a torn left groin against the Warriors, which was the first major injury of his career. It submarined both his and his team's season.
The 17-year veteran came back a model of good health this season, averaging 25.5 points, 7.7 rebounds and a league-best 10.6 assists per game for the Western Conference-leading Lakers.
He has played in 54 of the Lakers' 56 games this season, with one of those games he missed also due to groin discomfort.
Lakers forward Anthony Davis is listed as probable for the Warriors game, with a sore left elbow.
LeBron's first duel vs. Zion ends with season-high 40 points
LeBron James brings his A-game for his first meeting against Zion Williamson, scoring a season-high 40 points to defeat the Pelicans at home.