The suspect's motive remained a mystery, along with whether he acted alone in the five bombings in the Texas capital and suburban San Antonio that killed two people and wounded four others.
Police zeroed in on the 23-year-old man in the last 24 to 36 hours and located his vehicle at a hotel on Interstate 35 in the suburb of Round Rock. Officers were waiting for armored vehicles to arrive before moving in for an arrest when his vehicle began to drive away, Austin Police Chief Brian Manley said at a news conference.
Authorities followed the vehicle, which ran into a ditch on the side of the road, he said.
When members of the SWAT team approached, the suspect detonated an explosive device inside the vehicle, the police chief said. The blast knocked one officer back, and a second officer fired his weapon, Manley said.
WATCH: Raw video: Austin police give update on investigation involving bombings suspect
A law enforcement official identified the dead man as Mark Anthony Conditt. The official, who has been briefed on the investigation, spoke to The Associated Press on the condition of anonymity because the official was not authorized to discuss the case publicly.
The mayor of Pflugerville, an Austin suburb not far from the site of the first of four bombings, said the suspect lived in his city, just two blocks from his house.
Pflugerville resident Jay Schulze said he was jogging Tuesday night when he was stopped by police and asked about the bombings. He said police flew drones over a home for about six hours between Tuesday evening and early Wednesday morning.
He described the home over which the drones were flying as "a weird house with a lot of people coming and going" and a bit rundown.
Austin was hit with four package bombings starting on March 2. A fifth parcel bomb went off early Tuesday at a FedEx distribution center near San Antonio.
Citing a high-ranking law enforcement official, the Austin American-Statesman reported that authorities had identified the suspect based largely on information, including security video, gleaned after he sent an explosive device from an Austin-area FedEx store.
Police warned Wednesday of the possibility that more bombs had yet to be found.
"We don't know where this suspect has spent his last 24 hours, and therefore we still need to remain vigilant to ensure that no other packages or devices have been left to the community," Manley said.
Manley said the suspect is believed to be responsible for all the major Austin bombings.
AUSTIN BOMBING SUSPECT IS DEAD. Great job by law enforcement and all concerned!— Donald J. Trump (@realDonaldTrump) March 21, 2018
To say all of your colleagues across the Nation are proud of you, @Austin_Police, @ATFHou, @FBI & all who worked courageously & tirelessly, would be understatement. Now let’s remove that interim title & build the Department which is long overdue. Congratulations. https://t.co/fjdwxnWzIA— Chief Art Acevedo (@ArtAcevedo) March 21, 2018
Authorities initially believed the bombings may be hate crimes because the victims of the earliest blasts were black, but they backed off that theory after Hispanic and white victims from different parts of the city were also affected. The suspect was described as white.
Fred Milanowski, an agent with the U.S. Bureau of Alcohol, Tobacco, Firearms and Explosives, said it was "hard to say" if the bombing suspect had acted alone.
"What we do know is we believe the same person built each one of these devices," said Milanowski, the agent in charge of the Houston division of the ATF. "We are not 100 percent convinced there's not other devices out there."
Asked if the suspect built bombs before the Austin attacks, Milanowski said: "We know when he bought some of the components. It's hard to say whether he was building along the way."
Austin Mayor Steve Adler thanked law enforcement for their work in bringing down the suspect and urged residents to continue to report anything that appeared suspicious or out of place.
Isaac Figueroa, 26, said he and his brother heard sirens and helicopters early Wednesday in the area and drove toward them, then cut through nearby woods on foot after they hit a police roadblock.
Figueroa said they saw a silver or gray Jeep Cherokee that was pinned between black and white vehicles and "looked like it had been rammed off the road." He said he saw police deploy a robot to go examine the Jeep.
President Donald Trump, who had earlier said whoever was responsible for the Austin bombings was "obviously a very sick individual or individuals," tweeted, "AUSTIN BOMBING SUSPECT IS DEAD. Great job by law enforcement and all concerned!"
The suspect's death followed a day of rapid-fire developments in the case.
On Tuesday, a bomb inside a package exploded around 1 a.m. as it passed along a conveyor belt at a FedEx shipping center in Schertz, northeast of San Antonio and about 60 miles (95 kilometers) southwest of Austin. One worker reported ringing in her ears and was treated at the scene.
Later in the morning, police sent a bomb squad to a FedEx facility outside the Austin airport to check on a suspicious package. Federal agencies and police later said that package had indeed contained an explosive that was successfully intercepted and that it, too, was tied to the other bombings.
The Schertz blast came two days after a bombing wounded two men Sunday night in a quiet Austin neighborhood about 3 miles (5 kilometers) from the FedEx store. It was triggered by a nearly invisible tripwire, suggesting a "higher level of sophistication" than agents saw in three package bombs previously left on doorsteps, Milanowski said.
The Associated Press contributed to this report.