CHP officers responded to the crash site, near Santa Anita Avenue, shortly before 4 a.m., according to a Highway Patrol incident log.
The number and extent of injuries were not immediately clear.
All lanes were reopened just after 5:30 a.m., the CHP said in a tweet.
The cause of the crash was unknown.
CANCELED SIGALERT AT WB SR-60 JEO SANTA ANITA BLVD, ROADWAY CLEAR— CHP PIO - LA County (@CHPsouthern) April 19, 2019