Crews will stabilize hillsides and repair infrastructure damaged in the blaze.
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Closures are slated to be in place between 8:30 a.m. and 3:30 p.m. on the right lane and shoulder of the northbound side along a 20-mile stretch from Topanga Canyon Road to Decker Canyon.
Caltrans says work will take place every day of the week except Sunday, weather permitting.
Drivers should expect delays and leave extra time to reach their destinations.