The pursuit began shortly before 1 a.m. when the driver failed to yield to Culver City police, according to the California Highway Patrol. The Honda Odyssey made its way onto the 405 Freeway and crashed on the Sepulveda Boulevard off-ramp.
Firefighters arrived at the scene to find the vehicle in flames; they used the Jaws of Life to extract the occupants.
An unidentified woman, approximately 25 years old, was pronounced dead at the scene. Three others were transported to a hospital with serious injuries.
The male driver was arrested on suspicion of DUI and vehicle theft, the CHP said. His name was not immediately released.