The truck rolled over near Interstates 70 and 465 on the east side of Indianapolis, an Indiana State Police spokesman tweeted just after 1:15 p.m. Police video shows fire surrounding first responders after the crash.
A good Samaritan pulled the driver out of the truck, according to local law enforcement. He was transported to a hospital.
"This will be a very extended clean-up and will affect rush hour traffic," police said. "Expect long delays."
Motorists should seek alternate routes if they're in the area.