The solo vehicle rollover crash was reported around 3:30 a.m., prompting the closure of I-10 in both directions between Ramsey and Eighth streets for hazmat removal, according to the Riverside County Fire Department.
The cause of the crash was not immediately known.
Shortly after 9 a.m., Caltrans and county fire officials reported that all westbound lanes and two of the four eastbound lanes were reopened, with about 4,500 gallons of fuel remaining on the roadway.
Caltrans advised on Twitter that all eastbound lanes will be closed again at an unknown time to offload more fuel from the tanker.