The crash was reported around 2 a.m. at Overland Avenue near the Palms and Rancho Park neighborhoods, according to the California Highway Patrol's traffic log.
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One person died at the scene, and three others were hospitalized.
The cause of the crash is under investigation, but there were reports of a possible wrong-way driver.
All westbound lanes remained closed until about 7:30 a.m.
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DEVELOPING: We will add more details to this report as they become available.