The crash was reported around 2 a.m. at Overland Avenue near the Palms and Rancho Park neighborhoods, according to the California Highway Patrol's traffic log.
One person died at the scene, and three others were hospitalized.
The cause of the crash is under investigation, but there were reports of a possible wrong-way driver.
All westbound lanes remained closed until about 7:30 a.m.
DEVELOPING: We will add more details to this report as they become available.