The incident was reported about 5:30 a.m. on the eastbound side of the freeway, near the 710 Freeway interchange, according to the California Highway Patrol. A SigAlert was issued and a stretch of the eastbound side of the 10 Freeway was closed between City Terrace and Monterey Park.
Two patients, identified only as males, were transported to a hospital and were undergoing surgery, said Officer Marco Lizarraga, a CHP spokesperson. Details of their injuries were not immediately known.
A bullet hole was found in the passenger-side door of a white Honda Accord that was later towed from the scene.
No one was in custody in connection with the incident, which Lizarraga said was being investigated as an apparent car-to-car shooting. A description of the suspected shooter was not available.
Highway Patrol officers were seen searching for evidence in the shut-down lanes. Eastbound traffic was backed up for miles amid the morning commute.
About 8:30 a.m., the CHP announced that all lanes were reopened on the freeway.
Editor's note: This report has been updated to clarify that the shooting occurred in City Terrace, while the length of the freeway closure extended into nearby Monterey Park.