The crash was reported shortly before 9:30 a.m. near Laurel Canyon Boulevard, according to the Los Angeles Fire Department, resulting in the closure of all lanes.
The incident led to approximately 75 gallons of fuel spilling, with some making it into the storm drain before firefighters arrived with barriers.
No injuries were reported, and LAFD Hazmat crews responded to assist in the evaluation.
The SigAlert was extended to at least 1:45 p.m., the California Highway Patrol reported. All lanes were back open by about 2 p.m.