The incident was reported around 5:40 a.m. near the 5 and 101 Freeway interchange. The California Highway Patrol shut down the northbound 5 Freeway transition to the northbound 101 Freeway due to the investigation.
All lanes of the transition road were reopened shortly after 8:30 a.m.
Los Angeles police said several vehicles were involved in the crash with the pedestrian, and it's believed that one of the cars involved may have been an off-duty LAPD officer in a personal vehicle.
No further details were immediately available.