The injured patients were described as a young child or infant described as being in grave condition, a woman in serious condition and a man in fair condition.
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Footage from AIR7 HD showed one car flipped over on its roof in westbound lanes as paramedics treated a woman and then moved her on a stretcher into an ambulance. Another patient at the scene appeared to be a man who was conscious and sitting upright with only minor injuries.
One of the vehicles apparently involved in the crash was a big rig, which was pulled over at the scene with damage to its front engine area. Another vehicle at the scene, which remained upright, was a Mini Cooper.
The crash was reported around 1:30 p.m. on the freeway near the Tujunga Avenue ramp. One person was trapped in the wreckage but was freed without the use of hydraulic tools.
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At least one lane of traffic was allowed to move past the scene of the crash.
The cause of the crash was under investigation.