It happened shortly after 8:15 p.m. near Woodman Avenue on the northbound side of the 101.
Six people were injured, according to the Los Angeles Fire Department. A 27-year-old man was taken to a nearby hospital with a severed leg, a 56-year-old man suffered an ankle injury and one woman was taken to a hospital with unknown injuries.
Three other patients declined to be transported.
The crash shut down three lanes of the busy freeway.
The cause of the wreck was not yet known.