The crash was reported around 3:45 a.m. at Alvarado Street, according to the California Highway Patrol.
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The pedestrian was hit by a semi-truck, but it's unclear what that person was doing on the freeway.
The closure created a traffic mess for early morning commuters, who were being diverted at Vermont Avenue, as authorities worked to clear lanes.
At 7:45 a.m., the CHP tweeted that all lanes would remain shut down for an additional 30 minutes.
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