One person died in the crash that was reported at 4:46 a.m. on the southbound 101 Freeway at the Pilgrimage Bridge, according to the California Highway Patrol.
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Authorities are investigating the case as a hit-and-run incident after witnesses say the driver of a box truck struck the victim's car as she was getting out and then fled the scene. The driver of another car was also reported as striking the woman's car.
A Sigalert was issued around 5 a.m. and lanes reopened around 9:40 a.m. Before lanes reopened, CHP said traffic was being diverted off at Highland Avenue.
A hazmat team was called to the scene.
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Further details about the crash were not immediately available. Authorities said the color of the box truck is red and white.