The crash occurred around 5 a.m. on Melrose Avenue near Ardmore Avenue, according to the California Highway Patrol.
The Melrose Avenue off-ramp was closed during the investigation. All southbound lanes beginning at Santa Monica Boulevard were temporarily closed but reopened around 6:15 a.m.
The age, gender and name of the victim were not disclosed. A vehicle description was not immediately released.
DEVELOPING: This report will be updated.
City News Service contributed to this report.