The Los Angeles Fire Department said all eight patients were transported via ambulances. According to a traffic incident log, an infant was among the injured.
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The eight victims were taken to hospitals with unspecified injuries, though the LAFD noted none were critically injured.
The crash happened just before 4 p.m. and involved five vehicles, LAFD reported. A van with front-end damage was seen on the side of the freeway.
Traffic on the eastbound 105 Freeway in the area was impacted as authorities cleared the collision. Footage from the scene showed most lanes were shut down and traffic was moving slowly.
The cause of the crash was under investigation.
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City News Service contributed to this report.