The crash happened just before 2:30 a.m. on eastbound lanes near Normandie Avenue, according to the California Highway Patrol.
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When firefighters arrived, a mangled car lodged in a tree was completely engulfed in flames.
The people who died have not been identified, and details about what led up to the crash have not been released. Early reports indicated that it could've been related to street racing, but authorities have not confirmed that.
At least two were expected to remain closed until about 7 a.m. during the investigation.
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It's unclear if any arrests have been made.
DEVELOPING: We will add more details to this report as they become available.