Fire crews and the California Highway Patrol responded to the crash at Manchester Avenue at about 3:30 a.m. When they arrived, they found a motorcyclist who had been struck by a vehicle, authorities said.
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The victim died at the scene. Information on the other vehicle involved was not immediately known.
The cause of the crash was under investigation.
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The three right lanes of the northbound 110 were shut down for several hours overnight and through the early morning, along with the Manchester Avenue off-ramp. All lanes were reopened at 8 a.m.