A Sigalert was canceled and all lanes were reopened near Slauson Avenue just after 5 a.m. Monday after a cleanup operation at the scene, according to the California Highway Patrol.
The deceased were not immediately identified, and the conditions of the injured were unknown.
The incident initially triggered a complete shutdown of the northbound 110 and a massive response from CHP officers, firefighters and paramedics. Its cause is under investigation.