The closure, located at Woodley Avenue, is expected to last through about 12:30 p.m., according to the California Highway Patrol.
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The crash is believed to involve multiple other vehicles, one of which was spotted being loaded onto a tow truck.
The westbound side of the freeway also appeared to be impacted as onlookers drove past the large overturned semi truck.
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Morning commuters were backed up for several miles as emergency crews worked to investigate the crash and clear the scene from a minor fuel spill.