According to the California Highway Patrol, the collision happened about 4 a.m. just west of Topanga Canyon Boulevard. Westbound traffic was being diverted onto that street as a SigAlert was issued.
Lanes were reopened around noon, according to a tweet by Caltrans.
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No injuries were immediately reported.
Firefighters who responded to the scene managed to contain a fuel spill, the CHP said.
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The official cause of the crash has not been determined. Light rain had been falling in Chatsworth and throughout the Southland at the time of the incident.