The crash was reported just before 5 a.m. near Glendale Avenue, according to the California Highway Patrol's traffic log.
Westbound lanes of 134 Freeway shut down in Glendale after deadly big rig crash
Details about what led up the incident were not available, but the big rig appears to have struck a white sedan, killing the person in that vehicle.
AIR7 HD was over the scene where cars were only able to drive on the right shoulder to get past the crash.
All lanes were reopened to drivers around 9 a.m.