According to California Highway Patrol, reports of a shooting began coming in at around 7:45 p.m. near the Nisqualli Road exit.
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Authorities say a GMC vehicle and a sedan approached Nisqualli Road and each of the drivers then stopped on the right shoulder of the offramp and exited their vehicles. The driver of the sedan then fatally shot the driver of the GMC vehicle, according to authorities.
The gunman fled the scene in an unknown direction.
All northbound lanes of the 15 Freeway were temporarily shut down. Two lanes had reopened by 1 a.m. Friday.
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Anyone with information on the shooting is asked to contact the California Highway Patrol's Inland Division at (909) 806-2484.