Officers with the Victorville Police Department responded to a call about an assault with a weapon near Bear Valley Road and Mall Boulevard Sunday night.
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According to an update issued by the San Bernardino Sheriff's Department, that's where officers found 22-year-old Brock Moore on the ground with a gunshot wound.
He was rushed to the hospital where he later died.
The suspect, identified as 23-year-old Jeremy Franks, fled the scene but was later found in Barstow.
He was taken into custody and was booked into the High Desert Detention Center for murder, authorities said.
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"At this time, it appears the incident started over a road rage clash," read a statement by the sheriff's department.
Anyone with information on this case is urged to contact Det. Chris Crosswhite at 909-890-4904.
Callers can remain anonymous and contact We-Tip at 800-78CRIME or www.wetip.com.