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Susana and Jason Almarez were last seen on the 2500 block of Garnet Lane at 4 p.m. Wednesday, the Sheriff's Information Bureau said.
Susana is being described as a 5-foot-8-inch Hispanic girl, weighing about 180 pounds with long black hair and a heart tattoo under her left eye. She was last seen wearing a gray tank top and gray/pink pajama pants.
Jason was last seen wearing a yellow onesie.
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Anyone with information is urged to call the Lancaster Sheriff's Station detective bureau at 661-948-8466. Anonymous callers can call Crime Stoppers at 800-222-8477 or send tips to lacrimestoppers.org.
City News Service, Inc. contributed to this report.